Search Results for heme
using database Escherichia coli K-12 substr. MG1655 ^{what is this?}

Pathways (7) | Genes (1) | Proteins (36) | Compounds (17) | Gene Ontology Terms (24) | Reactions (5) | EC Numbers (7) | Transcription Units (1)

Pathways	Pathway pages contain: Depiction of metabolic pathway, of chromosomal locations of pathway genes, and of regulation of pathway genes.

• heme b biosynthesis II (oxygen-independent)
  
• heme b biosynthesis V (aerobic)
  
• Class: Heme b Biosynthesis
  
• Class: Heme Biosynthesis
  
• Class: Heme Degradation
  
• siroheme biosynthesis
  
• superpathway of heme b biosynthesis from uroporphyrinogen-III
  

Genes	Gene/Gene Product pages contain: chromosomal location of gene; depiction of its operon; link to genome browser; detailed summaries and citations; subunit structure (for protein complexes); cofactors, activators, and inhibitors (for enzymes), depiction of regulon (for transcriptional regulators), protein features.

• hemE
  

Proteins	Gene/Gene Product pages contain: chromosomal location of gene; depiction of its operon; link to genome browser; detailed summaries and citations; subunit structure (for protein complexes); cofactors, activators, and inhibitors (for enzymes), depiction of regulon (for transcriptional regulators), protein features.

• uroporphyrinogen decarboxylase (HemE)
  
• heme ABC transporter CydDC
  
• heme ABC transporter subunit CydC
  
• heme ABC transporter subunit CydD
  
• heme chaperone HemW (polypeptide)
  
• heme chaperone HemW (protein complex)
  
• heme O synthase
  
• heme-containing peroxidase/deferrochelatase (polypeptide)
  
• heme-containing peroxidase/deferrochelatase (protein complex)
  
• catalase HPII (heme d synthase)
  
• CcmAB (release of heme-bound CcmE)
  
• CcmCDE complex (heme binding and reduction)
  
• Class: a CcmE-[c-type cytochrome--CcmH disulfide] complex (CytC-CcmH-Heme-CcmE)
  
• Class: a heme(II)-bound CcmE protein
  
• Class: a heme(III)-bound CcmCDE complex
  
• Class: a heme(III)-bound CcmE protein
  
• Class: an R-2-hydroxy-3-methylpentanoate-methylvaline-phenylalanine-methylphenylalanine-proline-allo-isoleucyl-[acp] (R-Hmp-MeVal-Phe-MePhe-Pro-alle-ACP)
  
• Class: an R-2-hydroxy-3-methylpentanoate-methylvaline-phenylalanine-methylphenylalanine-prolyl-[acp] (R-Hmp-MeVal-Phe-MePhe-Pro-ACP)
  
• Class: an R-2-hydroxy-3-methylpentanoate-methylvaline-phenylalanine-methylphenylalanyl-[acp] (R-Hmp-MeVal-Phe-MePhe-ACP)
  
• Class: an R-Hmp-MeVal-Phe-MePhe-Pro-alle-MeVal-Leu-MeVal-[acp]
  
• Class: an R-Hmp-MeVal-Phe-MePhe-Pro-alle-MeVal-Leu-[acp]
  
• Class: an R-Hmp-MeVal-Phe-MePhe-Pro-alle-MeVal-[acp]
  
• cytochrome c maturation protein A (heme trafficking system protein A)
  
• cytochrome c maturation protein B (heme trafficking system protein B)
  
• cytochrome c peroxidase (tri-heme CCP)
  
• ferritin iron-storage complex (non-heme bacterial ferritin)
  
• ferrochelatase (protoheme ferro-lyase)
  
• holocytochrome c synthase CcmF component (cytochrome c heme lyase)
  
• holocytochrome c synthase complex (heme-ligase complex)
  
• membrane-bound flavocytochrome MsrQ (periplasmic protein-L-methionine sulfoxide reductase heme binding subunit)
  
• oxygen-sensing c-di-GMP phosphodiesterase DosP (c-di-GMP phosphodiesterase, heme-regulated)
  
• periplasmic nitrite reductase penta-heme c-type cytochrome
  
• periplasmic heme chaperone
  
• putative heme-binding protein GlcG
  
• siroheme synthase (polypeptide)
  
• siroheme synthase (protein complex)
  

Compounds	Compound pages contain: compound structural information, and links to all reactions and pathways in which the compound participates.

• cis heme d
  
• trans heme d
  
• Class: heme a
  
• Class: heme b
  
• Class: heme c
  
• Class: heme d
  
• Class: heme d₁
  
• Class: heme i
  
• Class: heme o
  
• Class: a heme-thiolate prosthetic group
  
• Class: a heme
  
• ferriheme b
  
• ferroheme o
  
• homotaurine (Alzhemed)
  
• mesoheme
  
• protoheme
  
• siroheme
  

Gene Ontology Terms	GO term pages contain: Parent and child terms, and lists of matching gene products. Note that only those terms that have one or more associated genes in the selected organism (or that have children with one or more associated genes) are listed.

Biological Process

• Class: GO:0006783 - heme biosynthetic process
  
• Class: GO:0006785 - heme B biosynthetic process
  
• Class: GO:0006788 - heme oxidation
  
• Class: GO:0015886 - heme transport
  
• Class: GO:0017003 - protein-heme linkage
  
• Class: GO:0018063 - cytochrome c-heme linkage
  
• Class: GO:0019354 - siroheme biosynthetic process
  
• Class: GO:0035351 - heme transmembrane transport
  
• Class: GO:0042167 - heme catabolic process
  
• Class: GO:0042168 - heme metabolic process
  
• Class: GO:0046156 - siroheme metabolic process
  
• Class: GO:0046492 - heme B metabolic process
  
• Class: GO:0048033 - heme O metabolic process
  
• Class: GO:0048034 - heme O biosynthetic process
  
• Class: GO:0140420 - heme import into cell
  
• Class: GO:1904334 - heme import across plasma membrane
  

Molecular Function

• Class: GO:0004325 - ferrochelatase activity
  
• Class: GO:0008495 - protoheme IX farnesyltransferase activity
  
• Class: GO:0015232 - heme transmembrane transporter activity
  
• Class: GO:0015439 - ABC-type heme transporter activity
  
• Class: GO:0016675 - oxidoreductase activity, acting on a heme group of donors
  
• Class: GO:0016677 - oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
  
• Class: GO:0020037 - heme binding
  
• Class: GO:0042279 - nitrite reductase (cytochrome, ammonia-forming) activity
  

Reactions	Reaction pages contain: reaction equation with chemical structures, links to all enzymes that catalyze the reaction, and all pathways in which the reaction participates.

• (2E,6E)-farnesyl diphosphate + protoheme + H₂O → ferroheme o + diphosphate
  
• heme b + hydrogen peroxide → heme d
  
• ATP + protoheme_[cytosol] + H₂O → ADP + protoheme_[periplasm] + phosphate + H⁺
  
• protoheme + 2 H⁺ ↔ protoporphyrin IX + Fe²⁺
  
• sirohydrochlorin + Fe²⁺ → siroheme + 2 H⁺
  

EC Numbers	EC Number pages contain: links to reaction and enzymes associated with the EC number in this database, names, description, citations, etc. from the Enzyme Commission ontology.

• 1.7.2.2 -- nitrite reductase (cytochrome; ammonia-forming) (multiheme nitrite reductase)
  
• 1.11.1.7 -- peroxidase (heme peroxidase)
  
• 1.16.3.2 -- bacterial non-heme ferritin
  
• 2.5.1.141 -- heme o synthase
  
• 4.98.1.1 -- protoporphyrin ferrochelatase (protoheme ferro-lyase (protoporphyrin-forming))
  
• 4.99.1.4 -- sirohydrochlorin ferrochelatase (siroheme ferro-lyase (sirohydrochlorin-forming))
  
• 7.6.2.5 -- ABC-type heme transporter
  

Transcription Units	Transcription Unit pages contain: Detailed information about gene regulation including location of promoter and transcription factor binding sites, and regulators that control the promoter.

• nudC-hemE-nfi
  

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Page generated by Pathway Tools version 29.0 (software by SRI International) on Mon Jun 30, 2025, BIOCYC18A.
EcoCyc version 29.0.