Tier 2 Curated Organism Database Acinetobacter baumannii ATCC 17978 | |
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Summary | Acinetobacter baumannii is considered the most important nosocomial species of the genus Acinetobacter [Peleg08] due to its antimicrobial resistivity. It is a oxidase-negative aerobe, coccobacillus, capable of non-flagellated motility and biofilm formation, and is a cause of a range of both community and hospital-acquired infections. Some strains, capable of "escaping' the biocidal action of most antibiotics, are currently responsible for the majority of hospital infections in the U.S., placing them among the list of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) of major concern for public health [Boucher09]. Carbapenem-resistant Acinetobacter baumannii are also on the list of critical priority bacteria for investment in new drugs [Tacconelli18]. The phylogeny and taxonomy of Acinetobacter has changed significantly since its initial discovery in the early 20th century when it was originally designated as Micrococcus and subsequently reclassified as Acinetobacter in 1950 [Peleg08]. The species Acinetobacter baumannii was named and described in the mid-1980s with ATCC 19606 being designated as the type strain [Bouvet86]). The strain ATCC 17978 is a clinical isolate from 1951 originally named Moraxella glucidolytica nonliquefaciens [Baumann68]. Its genome, sequenced in 2007, is 3,976,746 bp with 3830 ORFs. The genome contains multiple pathogenicity islands that encode genes associated with virulence, such as Type IV secretion systems, drug and heavy metal resistance proteins, fimbriae, and mobile elements [Smith07]. The complete genome presented here is from a substrain, PMR-High, of the original ATCC 17978 strain isolated in vitro from "luria agar plate containing polymyxin B 16 μg/ml" (information from NCBI BioSample: SAMN11304550) submitted on 04-APR-2019 and updated 25-JUL-2019 and contains two unnamed plasmid sequences. This Pathway/Genome Database (PGDB) was generated by the PathoLogic [Karp11, Karp16] component of Pathway Tools software version 24.5 and MetaCyc [Caspi18] version 24.1 on 06-Jun-2020. Development of this PGDB was supported by BioCyc subscription revenues and by grant GM080746 from the National Institute of Health. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Genome |
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Database Contents |
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Database Version | 29.0 |
Taxonomic Lineage | cellular organisms Bacteria <bacteria> Pseudomonadota Gammaproteobacteria Moraxellales Moraxellaceae Acinetobacter Acinetobacter calcoaceticus/baumannii complex Acinetobacter baumannii Acinetobacter baumannii ATCC 17978 |
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Genetic Code Number | 11 -- Bacterial, Archaeal and Plant Plastid (same as Standard, except for alternate initiation codons) |
BIOSAMPLE | SAMN11304550 |
NCBI BioProject | PRJNA224116 |
NCBI-Taxonomy | 400667 |
Geographic Location | South Korea |
Collection Date | 2017-12-29/2018-01-29 |
Relationship to Oxygen | aerobe |
Trophic Level | heterotroph |
Temperature Range | mesophile |
Health/Disease State | pathogen |
Annotation Provider | NCBI RefSeq |
Annotation Pipeline | NCBI Prokaryotic Genome Annotation Pipeline (PGAP) |
Annotation Pipeline Version | 4.11 |
Annotation Comment | Best-placed reference protein set; GeneMarkS-2+ |
References
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