Database Authors
Bridget ChukuAlim, International Trypanotolerance Center, The Gambia; Nick Peters, Wellcome Trust Sanger Institute, UK; Matthew Berriman, Wellcome Trust Sanger Institute, UK
Summary Trypanosoma brucei is a parasitic kinetoplastid that is the cause of a vector-borne disease of vertebrate animals, including humans, carried by different species of tsetse flies (Glossina) in sub-Saharan Africa. In humans the organism causes African trypanosomiasis, also known as the sleeping sickness.

This Pathway/Genome Database (PGDB) was generated by a team from the International Trypanotolerance Center, The Gambia, and the Wellcome Trust Sanger Institute in the UK.

The PGDB was created from the annotated genome using the PathoLogic component of the Pathway Tools software [Karp11, Karp19] and the MetaCyc reference database [Caspi20]. The PGDB, which integrates the biochemical reaction network and metabolic pathways of the organism with its genome, was improved by limited manual curation.

Genome
RepliconTotal GenesProtein GenesRNA GenesPseudogenesSize (bp)NCBI Link
Chromosome 112,0181,823561395,545,621
Chromosome 101,6671,53899304,053,925
Chromosome 91,6341,2261622463,057,347
Chromosome 890677779502,481,190
Chromosome 777273520172,205,233
Chromosome 362052742511,653,225
Chromosome 662250048741,618,915
Chromosome 55324485791,608,198
Chromosome 458653013431,590,432
Chromosome 235128425421,193,948
Chromosome 153249610261,064,672
Total:10,2408,88455979726,072,706
Ortholog data available?Yes
Database Contents
Genes10,240
Pathways298
Enzymatic Reactions1,122
Transport Reactions23
Polypeptides8,919
Protein Complexes11
Enzymes981
Transporters174
Compounds785
tRNAs65
Protein Features3,249
Database Version29.0
Taxonomic Lineage cellular organisms
Eukaryota
Discoba
Euglenozoa
Kinetoplastea
Metakinetoplastina
Trypanosomatida
Trypanosomatidae
Trypanosoma
Trypanozoon
Trypanosoma brucei
Genetic Code Number 1 -- Standard
NCBI-Taxonomy5691

References

Caspi20: Caspi R, Billington R, Keseler IM, Kothari A, Krummenacker M, Midford PE, Ong WK, Paley S, Subhraveti P, Karp PD (2020). "The MetaCyc database of metabolic pathways and enzymes - a 2019 update." Nucleic Acids Res 48(D1);D445-D453. PMID: 31586394

Karp11: Karp PD, Latendresse M, Caspi R (2011). "The pathway tools pathway prediction algorithm." Stand Genomic Sci 5(3);424-9. PMID: 22675592

Karp19: Karp PD, Midford PE, Billington R, Kothari A, Krummenacker M, Latendresse M, Ong WK, Subhraveti P, Caspi R, Fulcher C, Keseler IM, Paley SM (2019). "Pathway Tools version 23.0 update: software for pathway/genome informatics and systems biology." Brief Bioinform. PMID: 31813964

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