Database Authors
Summary Caulobacter vibrioides CB15 is an important model organism for studying the regulation of the cell cycle, asymmetric cell division, and cellular differentiation.

Upon division, Caulobacter cells produce two very different daughter cells.One daughter cell is a mobile "swarmer" cell that has a single flagellum at one cell pole that provides swimming motility for chemotaxis. The other daughter cell, called the "stalked" cell, has a tubular stalk structure protruding from one pole that has an adhesive holdfast material on its end, with which the stalked cell can adhere to surfaces. Swarmer cells differentiate into stalked cells after a short period of motility. Chromosome replication and cell division only occurs in the stalked cell stage.

The Caulobacter genus was historically divided into several types, one of which was called Caulobacter crescentus, based on its crescent shape, which is caused by the protein crescentin. However, Caulobacter crescentus strains were eventually re-classidied as Caulobacter vibrioides strains.

Caulobacter vibrioides CB15 was isolated in 1962 from pond water [POINDEXTER64]. Strain NA1000, which was derived from CB15 in the 1970s, is preferred by scientisits since it allows physical separation of the stalked and predivisional cells from each other.

The primary data source for this dataset was the full genome sequence, derived from Genbank accession AE005673 [Nierman01]. The Pathway/Genome Database, which integrates the biochemical reaction network and metabolic pathways of the organism with its genome, was generated computationally using the PathoLogic program [Karp99] and improved by limited manual curation. The work was performed as a collaboration of SRI International and Stanford University under the Stanford Microbial Cell project.

Genome
RepliconTotal GenesProtein GenesRNA GenesPseudogenesSize (bp)NCBI Link
Chromosome3,8183,7615704,016,947
Ortholog data available?Yes
Database Contents
Genes3,818
Pathways310
Enzymatic Reactions1,766
Transport Reactions69
Polypeptides3,769
Protein Complexes79
Enzymes917
Transporters202
Compounds1,413
Transcription Units2,632
tRNAs54
Transcriptional Regulation2
Protein Features4,666
GO Terms27,692
Database Version29.0 [History of Updates]
Synonyms Caulobacter vibrioides CB15
Caulobacter crescentus strain CB15
Caulobacter vibrioides ATCC 19089
Caulobacter crescentus
Caulobacter vibrioides NA1000
Caulobacter crescentus CB15
Taxonomic Lineage cellular organisms
Bacteria <bacteria>
Pseudomonadota
Alphaproteobacteria
Caulobacterales
Caulobacteraceae
Caulobacter
Caulobacter vibrioides
Caulobacter vibrioides CB15
Genetic Code Number 11 -- Bacterial, Archaeal and Plant Plastid (same as Standard, except for alternate initiation codons)
GOLD0000729
NCBI-Taxonomy190650
Relationship to Oxygenobligate-aerobe
Trophic Leveloligotroph
Temperature Rangemesophile
Biotic Relationshipfree-living
Copyright 2001-2019 SRI International, 2001-2009 Stanford University.


References

Karp99: Karp PD, Krummenacker M, Paley S, Wagg J (1999). "Integrated pathway-genome databases and their role in drug discovery." Trends Biotechnol 17(7);275-81. PMID: 10370234

Nierman01: Nierman WC, Feldblyum TV, Laub MT, Paulsen IT, Nelson KE, Eisen JA, Heidelberg JF, Alley MR, Ohta N, Maddock JR, Potocka I, Nelson WC, Newton A, Stephens C, Phadke ND, Ely B, DeBoy RT, Dodson RJ, Durkin AS, Gwinn ML, Haft DH, Kolonay JF, Smit J, Craven MB, Khouri H, Shetty J, Berry K, Utterback T, Tran K, Wolf A, Vamathevan J, Ermolaeva M, White O, Salzberg SL, Venter JC, Shapiro L, Fraser CM, Eisen J (2001). "Complete genome sequence of Caulobacter crescentus." Proc Natl Acad Sci U S A 98(7);4136-41. PMID: 11259647

POINDEXTER64: Pointdexter, J. S. (1964). "Biological properties and classification of the Caulobacter group." Bacteriol Rev 28;231-95. PMID: 14220656


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